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Page 1
Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion.
Müller D, Mukhopadhyay AK, Davidoff MS, Middendorff R. Müller D, et al. Reproduction. 2011 Aug;142(2):333-43. doi: 10.1530/REP-10-0517. Epub 2011 Apr 21. Reproduction. 2011. PMID: 21511885
However, prostatic PRKG1 expression increases with aging. Androgen withdrawal during temporary Leydig cell elimination induced a massive (>12-fold) upregulation of PRKG1 in prostate but not in other (penis and epididymis) androgen-dependent organs. These findings …
However, prostatic PRKG1 expression increases with aging. Androgen withdrawal during temporary Leydig cell elimination induced a mass …
TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p-dependent down-regulation of cGMP-dependent kinase 1.
Choi S, Park M, Kim J, Park W, Kim S, Lee DK, Hwang JY, Choe J, Won MH, Ryoo S, Ha KS, Kwon YG, Kim YM. Choi S, et al. J Biol Chem. 2018 Sep 21;293(38):14812-14822. doi: 10.1074/jbc.RA118.004220. Epub 2018 Aug 13. J Biol Chem. 2018. PMID: 30104414 Free PMC article.
Thus, the NF-kappaB/miR-155-5p/PKG1 axis may be crucial in the pathogenesis of inflammatory vascular diseases, such as atherosclerotic intimal hyperplasia and preeclamptic hypertension....
Thus, the NF-kappaB/miR-155-5p/PKG1 axis may be crucial in the pathogenesis of inflammatory vascular diseases, such as atherosclerotic intim …
Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene.
Sommer SL, Berndt TJ, Frank E, Patel JB, Redfield MM, Dong X, Griffin MD, Grande JP, van Deursen JM, Sieck GC, Romero JC, Kumar R. Sommer SL, et al. J Appl Physiol (1985). 2006 Feb;100(2):707-16. doi: 10.1152/japplphysiol.00306.2005. Epub 2005 Sep 15. J Appl Physiol (1985). 2006. PMID: 16166241 Free article.
In vascular tissues, expression of the gene is induced by mechanical stretch, and overexpression of the gene prevents injury-induced vascular smooth muscle hypertrophy and neointimal hyperplasia. We now show that deletion of the gly96/IEX-1 gene in mice is associated with …
In vascular tissues, expression of the gene is induced by mechanical stretch, and overexpression of the gene prevents injury-induced vascula …
In vivo blockade of α1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cells.
Stojkov NJ, Baburski AZ, Bjelic MM, Sokanovic SJ, Mihajlovic AI, Drljaca DM, Janjic MM, Kostic TS, Andric SA. Stojkov NJ, et al. Mol Hum Reprod. 2014 Jan;20(1):77-88. doi: 10.1093/molehr/gat052. Epub 2013 Jul 26. Mol Hum Reprod. 2014. PMID: 23894150
In the same Leydig cells, stress-decreased NOS3 expression was abolished, while stress-increased GUCY1 (cGMP 'producer') and PRKG1 (cGMP 'effector') were potentiated. It is possible that all molecules mentioned could contribute, at least in part, in recovery of Leydig cell …
In the same Leydig cells, stress-decreased NOS3 expression was abolished, while stress-increased GUCY1 (cGMP 'producer') and PRKG1 (c …
Orally applied doxazosin disturbed testosterone homeostasis and changed the transcriptional profile of steroidogenic machinery, cAMP/cGMP signalling and adrenergic receptors in Leydig cells of adult rats.
Stojkov NJ, Janjic MM, Kostic TS, Andric SA. Stojkov NJ, et al. Andrology. 2013 Mar;1(2):332-47. doi: 10.1111/j.2047-2927.2012.00035.x. Epub 2012 Nov 29. Andrology. 2013. PMID: 23413145 Free article.
Doxazosin (Doxa) is an alpha1-selective adrenergic receptor (ADR) antagonist widely used, alone or in combination, to treat high blood pressure, benign prostatic hyperplasia symptoms, and recently has been suggested as a potential drug for prostate cancer prevention/treatm …
Doxazosin (Doxa) is an alpha1-selective adrenergic receptor (ADR) antagonist widely used, alone or in combination, to treat high blood press …